Asymptotic Expansion for the Wave Function in a one-dimensional Model of Inelastic Interaction

We consider a two-body quantum system in dimension one composed by a test particle interacting with an harmonic oscillator placed at the position $a>0$. At time zero the test particle is concentrated around the position $R_0$ with average velocity $\pm v_0$ while the oscillator is in its ground state. In a suitable scaling limit, corresponding for the test particle to a semi-classical regime with small energy exchange with the oscillator, we give a complete asymptotic expansion of the wave function of the system in both cases $R_0 <a$ and $R_0 >a$.Comment: 23 page

Vitamin D: a review on its effects on muscle strength, the risk of fall, and frailty.

Vitamin D is the main hormone of bone metabolism. However, the ubiquitary nature of vitamin D receptor (VDR) suggests potential for widespread effects, which has led to new research exploring the effects of vitamin D on a variety of tissues, especially in the skeletal muscle. In vitro studies have shown that the active form of vitamin D, calcitriol, acts in myocytes through genomic effects involving VDR activation in the cell nucleus to drive cellular differentiation and proliferation. A putative transmembrane receptor may be responsible for nongenomic effects leading to rapid influx of calcium within muscle cells. Hypovitaminosis D is consistently associated with decrease in muscle function and performance and increase in disability. On the contrary, vitamin D supplementation has been shown to improve muscle strength and gait in different settings, especially in elderly patients. Despite some controversies in the interpretation of meta-analysis, a reduced risk of falls has been attributed to vitamin D supplementation due to direct effects on muscle cells. Finally, a low vitamin D status is consistently associated with the frail phenotype. This is why many authorities recommend vitamin D supplementation in the frail patient

A Quantum Model of Feshbach Resonances

We consider a quantum model of two-channel scattering to describe the mechanism of a Feshbach resonance. We perform a rigorous analysis in order to count and localize the energy resonances in the perturbative regime, i.e., for small inter-channel coupling, and in the non-perturbative one. We provide an expansion of the effective scattering length near the resonances, via a detailed study of an effective Lippmann-Schwinger equation with energy-dependent potential.Comment: 29 pages, pdfLaTe

Early detection of cyanobacterial blooms and associated cyanotoxins using fast detection strategy

Fast detection of cyanobacteria and cyanotoxins is achieved using a Fast Detection Strategy (FDS). Only 24 h are needed to unravel the presence of cyanobacteria and related cyanotoxins in water samples and in an organic matrix, such as bivalve extracts. FDS combines remote/proximal sensing techniques with analytical/ bioinformatics analyses. Sampling spots are chosen through multi-disciplinary, multi-scale, and multi-parametric monitoring in a three-dimensional physical space, including remote sensing. Microscopic observation and taxonomic analysis of the samples are performed in the laboratory setting, which allows for the identification of cyanobacterial species. Samples are then extracted with organic solvents and processed with LC-MS/MS. Data obtained by MS/MS are analyzed using a bioinformatic approach using the online platform Global Natural Products Social (GNPS) to create a network of molecules. These networks are analyzed to detect and identify toxins, comparing data of the fragmentation spectra obtained by mass spectrometry with the GNPS library. This allows for the detection of known toxins and unknown analogues that appear related in the same molecular network

A new prescription model for regional citrate anticoagulation in therapeutic plasma exchanges.

Regional citrate anticoagulation (RCA) is proposed for various extracorporeal purification techniques to overcome the risk of bleeding that might result from systemic anticoagulation. Yet, no individualized treatment protocol has been proposed for therapeutic plasma exchange (TPE) so far. The objective of this study was to assess the determinants of blood citrate concentration needed and to develop an individualized RCA protocol useful for clinical practice. The study population included 14 patients who underwent a total of 47 TPE sessions. Citrate was infused pre-plasmafilter. Post-plasmafilter and systemic plasma ionized calcium concentrations were measured at standardized time intervals. An algorithm was proposed for the supplementation of calcium. During the discovery phase, citrate was infused at a fixed starting rate, and adapted accordingly to obtained post-plasmafilter ionized calcium levels. Using a mathematical approach, an algorithm was thereafter developed for individualized prescriptions of citrate. Pre-treatment values of hematocrit and plasma ionized calcium were the main determinants of the required rate of citrate infusion. These can be integrated into a final equation enabling to individualize the prescription. A prefilter ionized calcium concentration between 0.24 and 0.33 mmol/l prevented coagulation of the extracorporeal circuit. Significant hypocalcemia occurred in 8.5% of treatments. There were no significant acid-base disturbances. We propose a new protocol, which enables for the first time to individualize the prescription of regional citrate anticoagulation during TPE, in an efficient manner. The immediately obtained regional anticoagulation protects against both the risk of coagulation of the membrane and the exposure to an excess of citrate

Erratum to: A new prescription model for regional citrate anticoagulation in therapeutic plasma exchanges.

BACKGROUND: Regional citrate anticoagulation (RCA) is proposed for various extracorporeal purification techniques to overcome the risk of bleeding that might result from systemic anticoagulation. Yet, no individualized treatment protocol has been proposed for therapeutic plasma exchange (TPE) so far. The objective of this study was to assess the determinants of blood citrate concentration needed and to develop an individualized RCA protocol useful for clinical practice. METHODS: The study population included 14 patients who underwent a total of 47 TPE sessions. Citrate was infused pre-plasmafilter. Post-plasmafilter and systemic plasma ionized calcium concentrations were measured at standardized time intervals. An algorithm was proposed for the supplementation of calcium. During the discovery phase, citrate was infused at a fixed starting rate, and adapted accordingly to obtained post-plasmafilter ionized calcium levels. Using a mathematical approach, an algorithm was thereafter developed for individualized prescriptions of citrate. RESULTS: Pre-treatment values of hematocrit and plasma ionized calcium were the main determinants of the required rate of citrate infusion. These can be integrated into a final equation enabling to individualize the prescription. A prefilter ionized calcium concentration between 0.24 and 0.33 mmol/l prevented coagulation of the extracorporeal circuit. Significant hypocalcemia occurred in 8.5% of treatments. There were no significant acid–base disturbances. CONCLUSION: We propose a new protocol, which enables for the first time to individualize the prescription of regional citrate anticoagulation during TPE, in an efficient manner. The immediately obtained regional anticoagulation protects against both the risk of coagulation of the membrane and the exposure to an excess of citrate. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12882-017-0494-9) contains supplementary material, which is available to authorized users

Monitoring cyanobacterial blooms during the COVID-19 pandemic in Campania, Italy: The case of lake avernus

Cyanobacteria are ubiquitous photosynthetic microorganisms considered as important contributors to the formation of Earth’s atmosphere and to the process of nitrogen fixation. However, they are also frequently associated with toxic blooms, named cyanobacterial harmful algal blooms (cyanoHABs). This paper reports on an unusual out-of-season cyanoHAB and its dynamics during the COVID-19 pandemic, in Lake Avernus, South Italy. Fast detection strategy (FDS) was used to assess this phenomenon, through the integration of satellite imagery and biomolecular investigation of the environmental samples. Data obtained unveiled a widespread Microcystis sp. bloom in February 2020 (i.e., winter season in Italy), which completely disappeared at the end of the following COVID-19 lockdown, when almost all urban activities were suspended. Due to potential harmfulness of cyanoHABs, crude extracts from the “winter bloom” were evaluated for their cytotoxicity in two different human cell lines, namely normal dermal fibroblasts (NHDF) and breast adenocarcinoma cells (MCF-7). The chloroform extract was shown to exert the highest cytotoxic activity, which has been correlated to the presence of cyanotoxins, i.e., microcystins, micropeptins, anabaenopeptins, and aeruginopeptins, detected by molecular networking analysis of liquid chromatography tandem mass spectrometry (LC-MS/MS) data

A time-dependent perturbative analysis for a quantum particle in a cloud chamber

We consider a simple model of a cloud chamber consisting of a test particle (the alpha-particle) interacting with two other particles (the atoms of the vapour) subject to attractive potentials centered in $a_1, a_2 \in \mathbb{R}^3$. At time zero the alpha-particle is described by an outgoing spherical wave centered in the origin and the atoms are in their ground state. We show that, under suitable assumptions on the physical parameters of the system and up to second order in perturbation theory, the probability that both atoms are ionized is negligible unless $a_2$ lies on the line joining the origin with $a_1$. The work is a fully time-dependent version of the original analysis proposed by Mott in 1929.Comment: 23 page

Decay of a Bound State under a Time-Periodic Perturbation: a Toy Case

We study the time evolution of a three dimensional quantum particle, initially in a bound state, under the action of a time-periodic zero range interaction with ``strength'' (\alpha(t)). Under very weak generic conditions on the Fourier coefficients of (\alpha(t)), we prove complete ionization as (t \to \infty). We prove also that, under the same conditions, all the states of the system are scattering states.Comment: LaTeX2e, 15 page

Policy and Information Systems implementation: The Greek Property Tax Information System Case

This study contributes to the literature on Information Systems (IS) implementation and provides insights into how IS implementation emerges as an assemblage constituted by diverse sociomaterial practices –that is, the intertwining of humans and technology in practice– during the implementation of Greece’s Yearly Property Tax policy and information system over the period 1997-2015. Drawing on the work of Deleuze, Guattari, and Delanda on ‘assemblage theory’ and Burke’s on motive (expressed as ‘intentionality’ and ‘motivation’) we discuss IS implementation as a performative process that is shaped by assemblage agents’ intentionality and motivation and conclude that explicitly attending to these dynamics during the emergence of policy and technology as a sociomaterial assemblage contributes to a better understanding of IS implementation and its success. We propose that higher levels of motivation and intentionality are related to higher chances of successful implementation. Finally, limitations and future research directions are proposed